Cystathionine beta-synthase-like protein

Author: uhhg

August undefined, 2024

WebBackground: Hyperhomocysteinemia often results from vitamin deficiency and/or an unhealthy lifestyle. Because the condition is a risk factor for developing cerebrovascular disease or atherosclerosis, approaches that decrease plasma homocysteine level WebThe CBS (Cystathionine Beta Synthase) gene, located on chromosome 21 in humans, encodes a pyridoxal 5′-phosphate-dependent enzyme catalysing the condensation of …

Cystathionine beta synthase - Wikipedia

WebCystathionine beta-synthase (CBS) is a key regulator of homocysteine metabolism. Although eukaryotic CBS have a similar domain architecture with a catalytic core and a C-terminal Bateman module, their regulation varies widely across phyla. In human CBS (HsCBS), the C-terminus has an autoinhibitory effect by acting as a cap that avoids the … WebOct 12, 2024 · Hydrogen sulfide (H 2 S) is an identified and recognized gasotransmitter after nitric oxide and carbon oxide. As endogenous methionine catalysis production, H 2 S major generates from homocysteine trans-sulfide metabolism. Cystathionine β synthase (CBS), cystathionine γ lyase (CSE), cysteine aminotransferase (CAT), and 3-mercaptopyruvate … how do bay boats do in rough water

LOC102724560 Gene - Cystathionine Beta-Synthase Like

WebMutations in the CBS, MTHFR, MTR, MTRR, and MMADHC genes cause homocystinuria.. Mutations in the CBS gene cause the most common form of homocystinuria. The CBS … WebAbstract. The cystathionine-beta-synthase (CBS) domain is an evolutionarily conserved protein domain that is present in the proteome of archaebacteria, prokaryotes, and … WebMar 21, 2024 · GeneCards Summary for CBS Gene. CBS (Cystathionine Beta-Synthase) is a Protein Coding gene. Diseases associated with CBS include Homocystinuria Due To Cystathionine Beta-Synthase Deficiency and Homocystinuria Caused By Cystathionine … AKR1C3 (Aldo-Keto Reductase Family 1 Member C3) is a Protein Coding gene. … AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, … GAL (Galanin And GMAP Prepropeptide) is a Protein Coding gene. Diseases … PHGDH (Phosphoglycerate Dehydrogenase) is a Protein Coding … ACHE (Acetylcholinesterase (Cartwright Blood Group)) is a Protein Coding gene. … HTT (Huntingtin) is a Protein Coding gene. Diseases associated with HTT include … CTNNB1 (Catenin Beta 1) is a Protein Coding gene. Diseases associated with … NTRK1 (Neurotrophic Receptor Tyrosine Kinase 1) is a Protein Coding gene. … how do bay leaves taste

National Center for Biotechnology Information

Cystathionine - an overview ScienceDirect Topics

WebCystathionine beta-lyase MetC Gene metC Status UniProtKB reviewed (Swiss-Prot) Organism Escherichia coli (strain K12) Amino acids 395 Protein existence Evidence at protein level Annotation score 5/5 Entry Feature viewer Publications External links History BLAST Download Add a publication Entry feedback Function WebCystathionine β-synthase deficiency is pleiotropic, with effects in the eye, skeleton, and central nervous and vascular systems ( Table 216-2 ). The eye and skeletal system … how do baylor students get football ticketsWebSep 9, 2024 · As mentioned above, cystathionine-β-synthase is an enzyme involved in the transsulfuration pathway, which is how the body regulates its levels of sulfur-containing … how do bayous form

"WebCystathionine beta-synthase, along with vitamin B6, converts homocysteine to cystathionine (see Fig. 5-8). A deficiency of this enzyme leads to accumulation not only … " - Cystathionine beta-synthase-like protein

Cystathionine beta-synthase-like protein

Structural basis of regulation and oligomerization of human ... - PNAS

WebWe reveal that, in normoxia, enzymatic action of cystathionine β-synthase (CBS) produces H 2 S, which persulfidates prolyl hydroxylase 2 (PHD2) at residues Cys 21 and Cys 33 (zinc finger motif), augmenting prolyl …

Did you know?

WebThe CBS gene provides instructions for making an enzyme called cystathionine beta-synthase. This enzyme acts in a chemical pathway and is responsible for using vitamin B6 to convert building block of proteins (amino acid) called homocysteine and serine to a molecule called cytathionine. Another enzyme then converts cystathionine to the amino ... WebApr 4, 2024 · protein coding gene: Chr17:31827868-31856212 (-) 129S1/SvImJ: ... IPR036052 Tryptophan synthase beta chain-like, PALP domain superfamily. Molecular Reagents less. All nucleic 28. Genomic 6. ... cDNA cloning and chromosomal mapping of cystathionine beta-synthase and the beta subunit of propionyl-CoA carboxylase. Proc …

WebHere, we report that the cystathionine β-synthase domain-containing protein CBSX2 located in the chloroplast plays a critical role in … WebFeb 1, 2012 · However, the pathway of cysteine biosynthesis was interrupted by a reaction catalyzed by the enzyme - cystathionine beta-synthase (CBS), which has no gene assignment in current S. meliloti genome annotation. In addition, production of CBS was observed in the proteomic assay as well . These evidences supported that the CBS …

WebHomocystinuria or HCU is an inherited disorder of the metabolism of the amino acid methionine due to a deficiency of cystathionine beta synthase or methionine synthase. It is an inherited autosomal recessive trait, which means a child needs to inherit a copy of the defective gene from both parents to be affected.Symptoms of homocystinuria can also … Allosteric activation of CBS by adoMet determines the metabolic fate of homocysteine. Mammalian CBS is activated 2.5-5-fold by AdoMet with a dissociation constant of 15 μM. AdoMet is an allosteric activator that increases the Vmax of the CBS reaction but does not affect the Km for the substrates. In other words, AdoMet stimulates CBS activity by increasing the turnover rate rather than the binding of substrates to the enzyme. This protein may use the morpheein model of allosteric regu…

WebUpregulation of cystathionine beta-synthetase expression by nuclear factor-kappa B activation contributes to visceral hypersensitivity in adult rats with neonatal maternal deprivation. Lanthionine synthetase C-like protein 1 interacts with and inhibits cystathionine beta-synthase: a target for neuronal antioxidant defense.

WebOur previous study demonstrated that cystathionine β synthase (CBS) is highly expressed in the cumulus–oocyte complex during ovulation. However, the role of CBS during oocyte maturation remains uncertain. In this study, a small-interfering (si) RNA interference (siRNA) approach was used to investigate the potential role of CBS during oocyte maturation. how do bays and headlands formWebThe CBS gene provides instructions for making an enzyme called cystathionine beta-synthase. This enzyme acts in a chemical pathway and is responsible for using vitamin … how do baymouth bars formWebOct 18, 2006 · We demonstrate that CBS is modified by the small ubiquitin-like modifier-1 protein (SUMO-I) under both in vitro and in vivo conditions. Deletion analysis of CBS indicates that the C-terminal regulatory domain is required for interaction with proteins in the sumoylation machinery. ... Cystathionine Beta Synthase Expression in Mouse Retina ... how do bays differ from estuariesWebFeb 6, 2024 · Cystathionine-β-synthase (CBS) is a modular enzymatic protein of 551 amino acids. The lyase CBS acts in the transsulfuration pathway and has a central role in the mammalian sulfur metabolism by ... how do bay leaves workWebDec 8, 2024 · 102724560 - Gene ResultLOC102724560 cystathionine beta-synthase like [ (human)] LOC102724560 cystathionine beta-synthase like [ (human)] Gene ID: 102724560, updated on 5-Aug-2024 Summary Other designations cystathionine beta-synthase, beta-thionase, cystathionine beta-synthase-like protein, serine sulfhydrase how do bbls workWebCystathionine beta-synthase (CBS) is a key regulator of homocysteine metabolism. Although eukaryotic CBS have a similar domain architecture with a catalytic core and a C … how do bay scallops moveWebBiosynthetically, cystathionine is generated from homocysteine and serine by cystathionine beta synthase (upper reaction in the diagram below). It is then cleaved … how do bbc make money