Organic anion transporter

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August undefined, 2024

WitrynaObjectives: Recent reports indicated that reduced SLC22A7 (a gene-encoding organic anion transporter 2) expression in noncancerous liver tissue predicts hepatocellular carcinoma (HCC) recurrence after curative resection. Our study aimed to elucidate the association between SLC22A7 expression and HCC development in chronic hepatitis … WitrynaThe organic anion transporters ( OAT s), part of the SLC22 superfamily of transporters, are expressed throughout the body. However, the most clinically …

Renal Drug Transporters and Drug Interactions - Springer

Witryna23 cze 2000 · Organic anion transporters play important roles in the elimination of a variety of endogenous substances, xenobiotics and their metabolites from the body. During the last decade, molecular cloning has identified several families of multispecific organic anion transporters mediating the renal and hepatic elimination of organic … Witryna9 paź 2012 · Organic anion transporters of the SLC22 family in human and rodent renal proximal tubule cells. As illustrated, human and rodent orthologs of OAT1/Oat1, OAT2/Oat2, OAT3/Oat3, OAT10/Oat10, and URAT1/Urat1 have been identified. Notable species differences are OAT4 having no identified rodent ortholog and Oat5 and Oat9 … marginalised define

Organic anion - Wikipedia

WitrynaKey words: organic anion transporter, transport, tubular excretion, drug interaction, kidney 〒181-8611三鷹市新川6-20-2. 68特集/トランスポーター ... Witryna Aims Witryna31. Takeda, M., et al., Characterization of organic anion transport inhibitors using cells stably expressing human organic anion transporters. Eur J Pharmacol, 2001. 419(2-3): p. 113-20. 32. Aslamkhan, A.G., et al., Human renal organic anion transporter 1-dependent uptake and toxicity of mercuric-thiol conjugates in Madin-Darby canine … marginalised families

Organic anion transporting polypeptide 1a/1b–knockout mice …

The organic anion transporter (OAT) family: a systems biology ...

WitrynaOrganic anion transporters (OATs) are the secondary/tertiary active transporter proteins that regulate anion balance in the body. They are primarily expressed in the … WitrynaNational Center for Biotechnology Information marginalised exampleWitryna5 paź 2010 · ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including … kuta inverse of a function

"Witryna9 lip 2024 · Organic anion transporting polypeptides (OATPs) are important transporter proteins that are expressed at the plasma membrane of cells, where they mediate the influx of endogenous and exogenous substances including hormones, natural compounds and many clinically important drugs. OATP1A2, OATP2B1, OATP1B1 … " - Organic anion transporter

Organic anion transporter

WitrynaNa +-independent transporter that mediates the cellular uptake of a broad range of organic anions such as the endogenous bile salts cholate and deoxycholate, either in … Members of the Organo Anion Transporter (OAT) Family (organic-anion-transporting polypeptides, OATP) are membrane transport proteins or 'transporters' that mediate the transport of mainly organic anions across the cell membrane. Therefore, OATPs are present in the lipid bilayer of the cell membrane, acting as the cell's gatekeepers. OATPs belong to the Solute Carrier Family (SLC) and the major facilitator superfamily.

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WitrynaThe SLC17 gene family encode proteins which are organic anion transporters. There are three distinct subfamilies within SLC17; vesicular glutamate transporters (VGLUT1-3 encoded by SLC17A7,6 and 8), type I Na+-coupled phosphate co-transporters (encoded by SLC17A1-4) and a proton-coupled sialic acid co-transporter (encoded by … WitrynaThis was the first organic anion transporter to be identified in the human placenta, where it is expressed abundantly and plays an important role in the uptake of organic anions from the fetus [6]. The expression of OAT4 along with OAT3 was confirmed by RT-PCR in the adrenal cortex as well as the adrenocortical cell line NCI-H295R [7]. …

WitrynaThe solute carrier (SLC) group of membrane transport proteins include over 400 members organized into 66 families. Most members of the SLC group are located in the cell membrane.The SLC gene nomenclature system was originally proposed by the HUGO Gene Nomenclature Committee and is the basis for the official HGNC names … Witryna9 wrz 2016 · Here, a novel multi-tiered systems biology approach was used to predict metabolites and signaling molecules potentially affected by the in vivo deletion of …

Witryna21 mar 2024 · SLCO4A1 (Solute Carrier Organic Anion Transporter Family Member 4A1) is a Protein Coding gene. Diseases associated with SLCO4A1 include Primary Hypertrophic Osteoarthropathy and Myasthenic Syndrome, Congenital, 1B, Fast-Channel.Among its related pathways are Transport of inorganic cations/anions and … Witryna1 sty 2015 · The organic anion transporter (OAT) subfamily, which constitutes roughly half of the SLC22 (solute carrier 22) transporter family, has received a great deal of …

WitrynaOfficial Symbol : Slco3a1 Official Name : solute carrier organic anion transporter family, member 3a1 EnsemblGene ID : Other Names : solute carrier family 21 (organic …

Witryna2. Grube, M., et al., Organic anion transporting polypeptide 2B1 is a high-affinity transporter for atorvastatin and is expressed in the human heart. Clin Pharmacol Ther, 2006. 80(6): p. 607-20. 3. Tamai, I., et al., Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. kuta inequalities worksheetWitryna30 paź 2024 · This family includes three subfamilies: organic cation transporter (OCT), organic cation transporter novel type (OCTN), and organic anion transporter (OAT). SLC22A1 (OCT1) is mainly expressed in the liver and is responsible for the uptake of dopamine and other substances into the liver. kuta hotels with poolCyclosporin A (CyA) has potent inhibitory activity on organic anion transporting polypeptide 1B (OATP1B), causing drug–drug interactions ... marginalised groups australiaWitryna1 lut 2006 · the organic anion (OA) transport system has been a major subject in renal physiology over the past 100 years, because this system represents the tubular secretory pathway. OAs include numerous substances of both endogenous and exogenous origins, and the renal OA transport system plays a pivotal role in the elimination of potentially … marginalised group of childrenWitrynaSolute carrier organic anion transporter family member 1B3. Alternative names. Liver-specific organic anion transporter 2 1 publication (LST-2 2 publications) OATP1B3 … kuta law of cosines worksheetWitryna18 maj 2010 · Protein names. Recommended name. Solute carrier organic anion transporter family member 5A1. Alternative names. Organic anion transporter … marginalised group disabilityWitryna2 lut 2024 · Organo-Anion-Transporter, kurz OATs, sind Membranproteine, die vorwiegend organische Anionen über Zellmembranen transportieren. Sie umfassen Proteine, die zur SLCO- und zur SLC22A-Superfamilie zählen. Erstere werden auch als "organic anion transporting polypeptides", kurz OATPs, bezeichnet. kuta integration by substitution