Phospho smad
WebIntroduction. Cancer-induced bone pain (CIBP) is a complex and multi-faceted response that includes both inflammatory and neuropathic components associated with tumor growth, bone destruction, and other factors. 2–4 CXCR4 is a receptor for CXCL12 (stromal-derived factor-1, SDF-1) and is a member of the seven-transmembrane G protein-coupled receptor … WebSMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by …
Phospho smad
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WebIn response to the TGF-beta signal, SMAD2 is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. WebAnti-phospho Smad1/Smad5/Smad8 (Ser463/465) AB3848-I Sigma-Aldrich Anti-phospho Smad1/Smad5/Smad8 (Ser463/465) Download Zoom Anti-phospho Smad1/Smad5/Smad8 (Ser463/465) Antibody, Cat. No. AB3848-I, is a highly specific rabbit polyclonal antibody that targets Smad1//5/8 phosphorylation and has been tested in Immunohistochemi More>>
WebThe Phospho-SMAD2 (Ser465/4267) assay measures SMAD2 when phosphorylated at Ser465/4267. Unlike Western Blot, the assay is entirely plate-based and does not require gels, electrophoresis, or transfer. ... HTRF assays facilitate investigation of the TGFB/SMAD/a-SMA signaling axis in liver fibrosis WebPhospho-SMAD3 (Ser423, Ser425) Antibody (600-401-919) in IHC (P) Rocklands affinity purified anti-Smad3 pS423 pS425 antibody was used at 2.5 µg/ml to detect signal in a variety of tissues including multi-human, …
WebThe Phospho-Smad5 (Ser463,Ser465) Antibody has been validated for the following applications: Western Blot. Western Blot analysis of Phospho-Smad5 (Ser463,Ser465) performed on various cell lines using a Phospho-Smad5 (Ser463,Ser465) monoclonal antibody (Product # MA5-35867) at a dilution of 1:1,000. An HRP Goat Anti-Rabbit IgG … WebProduct name Anti-Smad2 (phospho S467) antibody See all Smad2 primary antibodies Description Rabbit polyclonal to Smad2 (phospho S467) Host species Rabbit Tested applications Suitable for: WB, IHC-P more details Species reactivity Reacts with: Human Immunogen Synthetic peptide corresponding to Human Smad2 (phospho S467). …
WebPhospho-Smad4 (T277) ELISA Kit (ab279931) is a very rapid, convenient and sensitive assay kit that can monitor the activation or function of important biological pathways in human cell lysates. By determining phosphorylated Smad4 protein in your experimental model system, you can verify pathway activation in your cell lysates.
WebPhospho-Smad2 (S245/250/255) ELISA Kit (ab279929) is a very rapid, convenient and sensitive assay kit that can monitor the activation or function of important biological pathways in human cell lysates. By … involves both sexual and asexual reproductionWebImmunohistochemistry was performed to determine the expression of Smad transducer proteins in NFPAs. Ki-67 was evaluated as an indicator of the proliferative activity of … involve sb to do sthWebPhospho-SMAD1/SMAD5 (Ser463, Ser465) Antibody (700047) in ICC/IF Immunofluorescence analysis of SMAD1/5 (pS463/465) was done on 70% confluent log phase HeLa cells. The cells were fixed with 4% paraformaldehyde for 15 minutes, permeabilized with 0.25% Triton X-100 for 10 minutes, and blocked with 5% BSA for 1 … involve sb. in sthWebPhospho-Smad2 (Ser465/467)/Smad3 (Ser423/425) (D27F4) Rabbit mAb recognizes endogenous levels of Smad2 protein when phosphorylated at Ser465 and Ser467. This … involves by necessity crossword clueWebRLU = relative light units; p-SMAD2 = phospho-SMAD family member 2. Download Figure Download Powerpoint. Our data suggest that sustained Smad2 phosphorylation in response to TGF-β is dependent on Smad3 activity and is required for myofibroblast differentiation. While acknowledging the role of a canonical immediate Smad2/3-dependent gene ... involves by necessityWebFeb 2, 2024 · We detected both phospho-SMAD3 and phospho-SMAD2 in AR-negative PC3 cells in the absence of TGF-β treatment but those levels significantly increased after TGF-β treatment (Figure 3A). By contrast, phospho-SMAD3 and phospho-SMAD2 were undetectable in AR-positive Rv1 and C4-2 cells, regardless of TGF-β treatment (Figure 3A … involves by necessity crosswordWebThis study aimed to elucidate how HCV infection affected hepatic fibro-carcinogenesis, particularly via phospho-Smad signaling. Methods: We first studied phospho-Smad2/3 positivity of 100 patients in different stages of HCV-related chronic liver disease. To examine changes in phospho-Smad2/3 after HCV clearance, we analyzed 32 paired liver ... involves by-production of pyrophosphates