WebSpecifically, we use rolypoly to find enrichment of signal from association summary statistics of SNPs releaed by genome-wide association studies (GWAS) in cellular function annotations collected from RNA-seq (many times single-cell based cell types). WebMar 15, 2024 · Our package, rolypoly, is an implementation of the RolyPoly model for identifying trait-associated functional annotations. Specifically, we use rolypoly to find …
Inferring Relevant Cell Types for Complex Traits by Using Single-Cell
WebThe gene regulatory landscape of this dynamic system has not been fully characterized in human cells. Here we collected assay for transposase-accessible chromatin using sequencing (ATAC-seq) and... WebMay 29, 2024 · Europe PMC Multi-ancestry GWAS deciphers genetic architecture of abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target Roychowdhury T1, Klarin D2, Levin MG3, Spin JM4, Rhee YH4, Deng A4, Headley CA4, Surakka I1, Tsao NL5, Gellatly C6, Zuber V7, Shen F8, Hornsby WE1, Laursen IH9, Verma SS10, Locke AE11, … crack climbing machine
Genetic mapping of cell type specificity for complex traits
WebMay 2, 2024 · rolypoly_load_gwas ( rolypoly, gwas_data, snp_annotations = NULL, gwas_z_filter = -1, add_spline = F, n_knots = 1, add_poly = F, n_degree = 2) Arguments … WebRoly Poly Power is the power of choice. The food you choose to eat plays a prominent role in maintaining your overall well-being, health and vitality. We offer the freshest, nutrient rich … rolypoly This package is meant to identify enrichment of SNP-trait association signal in functional annotations. Install install.packages ("rolypoly") Usage For usage information see the introductory vignette. Additionally, refer to the manual for documentation of rolypoly functions. Notes Still in early alpha phase. Citation diva cup wash